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Tissue Regeneration Therapy

Partial amputation of a finger or other body part can be a life or career-altering event.  Fortunately, we have developed and refined technologies to assist in the regeneration of some or all of those tissues lost.

Extracellular Matrix (ECM) is a porcine-derived, 3-dimensional extracellular matrix that acts as a scaffold to support the body's own healing process by allowing cellular migration, vascular in-growth, and the formation of granulation tissue.  It provides a template for tissue in-growth and has been shown to aid in the healing of complex wounds caused by a variety of conditions. These materials have also been reported to be capable of regenerating missing tissues when used under appropriate conditions:

While we cannot fully explain the mechanism by which the scaffolds do what they do, we would like to reiterate that the technology DOES NOT have the ability to grow back entire digits.  Still, the scaffolds have already been used in many patients to regrow cartilage in sports injuries and regenerate missing tissue, such as that found in partial fingertip amputations.

Here is a link to some of Dr. Spiess’ research in this field:

Dr. Spiess' Research(opens in a new tab)

Person looking at hands

potential side effects

The use of ECM can result in complications. If any of these conditions occur, the device should be removed:

  • Infection 
  • Chronic inflammation (initial application of wound dressing may be associated with transient, mild, localized inflammation) 
  • Allergic reaction 
  • Excessive redness 
  • Pain 
  • Swelling 
  • Blistering


If you are ready to explore if your wound or injury is a candidate for tissue regeneration therapy, do not hesitate to contact Dr. Spiess and he will go over your options. You can utilize our online scheduling tool or call our office if you’re more comfortable speaking on the phone.

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