For some patients struggling with Dupuytren’s contracture, there is a non-surgical option that can help. XIAFLEX® is an FDA-approved, non-surgical treatment for adults with Dupuytren’s contracture when a “cord” can be felt. It starts breaking down the cord as soon as you receive the first injection. XIAFLEX® should be injected by a healthcare provider like Dr. Spiess, who is experienced in injection procedures of the hand and in treating people with Dupuytren’s contracture.
Reach out to Dr. Spiess’s office to schedule your first consultation today.
After injection, XIAFLEX® is thought to attach itself to the collagen that makes up the rope-like cord in the palm, unwinding the collagen and eventually breaking it down. However, the mechanism of action is not fully known. Studies show that prescription XIAFLEX®, along with a finger extension procedure, may help straighten or nearly straighten the affected finger and improve range of motion after up to 3 injections. 83% (206 out of 249) of patients were satisfied with XIAFLEX® compared with 30% (38 out of 125) of patients with placebo treatment.
In these 2 clinical studies, patients received up to 3 injections of XIAFLEX® or placebo into a cord that could be felt on Days 0, 30, and 60. About 24 hours after each injection, patients had a finger extension procedure and were fitted with a splint to wear at bedtime for up to 4 months. Patients also performed finger exercises every day. In these 2 studies, 60% of patients had a straight or nearly straight finger 30 days after the last injection on Days 30, 60, or 90 after up to 3 XIAFLEX® injections and finger extension procedures compared with 6% of patients who received placebo.
The most common side effects with XIAFLEX® in these studies were swelling of the injected hand and bruising or bleeding at the injection site, or lymph nodes. XIAFLEX® can cause serious side effects such as tendon rupture or ligament damage.
If you’re ready to experience the best surgical care available for your Dupuytren's contracture, you’ve found the right doctor. Reach out to Dr. Spiess’s office to schedule your first consultation today.